Blood coagulation disorders and its modulation system.

Disorders of the blood coagulation-fibrinolytic system

Most human cells have no direct contact with the external environment and their living conditions are ensured by blood. An essential criterion for normal blood circulation is the ability of the blood to arrest bleeding at sites of tissue injury and to prevent thrombus formation inside the blood vessels under normal conditions. The balance between these two extreme states is rigorously controlle...

Aptamer-based modulation of blood coagulation.

Nucleic acid based aptamers are single-stranded oligonucleotide ligands isolated from random libraries by an in-vitro selection procedure. Through the formation of unique three-dimensional structures, aptamers are able to selectively interact with a variety of target molecules and are therefore also promising candidates for the development of anticoagulant drugs. While thrombin represents the m...

[Disseminated intravasal blood coagulation disorders following injuries].

CLINICAL CONFERENCE Disorders of Coagulation of Blood

155 PEDIATRICS, January 1958 DR. SCHULMAN: The case we would like to discuss is one chosen for its own intrinsic interest, and also because it provides a good opportunity to illustrate some of our newer know!edge of coagulation in general, and hemophilia in particular. The patient is a 4-year-old boy who was referred to this hospital for investigation of a hemorrhagic diathesis. His birth was n...

Hereditary blood coagulation disorders: management and dental treatment.

Patients with hereditary hemostatic disorders, characterized by a tendency to bleeding or thrombosis, constitute a serious challenge in the dental practice. Advances in the medical diagnosis of hemostatic disorders have exposed dental professionals to new patients not amenable to the application of the management protocols associated with other, more well-known, disorders. It is the aim of this...